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Paper of the Month - February 2024
selected by the BMAS Scientific Board

Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction

Shuang Zhang, Alexandre Paccalet, David Rohde, Sebastian Cremer, Maarten Hulsmans, I-Hsiu Lee, Kyle Mentkowski, Jana Grune, Maximilian J. Schloss, Lisa Honold, Yoshiko Iwamoto, Yi Zheng, Miriam A. Bredella, Colleen Buckless, Brian Ghoshhajra, Vikas Thondapu, Anja M. van der Laan, Jan J. Piek, Hans W. M. Niessen, Fabio Pallante, Raimondo Carnevale, Sara Perrotta, Daniela Carnevale, Oriol Iborra-Egea, Christian Muñoz-Guijosa, Carolina Galvez-Monton, Antoni Bayes-Genis, Charles Vidoudez, Sunia A. Trauger, David T. Scadden, Filip K. Swirski, Michael A. Moskowitz, Kamila Naxerova & Matthias Nahrendorf

 
Nature Cardiovascular Research 2 2023; Dec 2023  –  https://www.nature.com/articles/s44161-023-00388-7
 
ABSTRACT

After myocardial infarction (MI), emergency hematopoiesis produces inflammatory myeloid cells that accelerate atherosclerosis and promote heart failure. Because the balance between glycolysis and mitochondrial metabolism regulates hematopoietic stem cell homeostasis, metabolic cues may influence emergency myelopoiesis. Here we show, in humans and female mice, that hematopoietic progenitor cells increase fatty acid metabolism after MI. Blockade of fatty acid oxidation by deleting carnitine palmitoyltransferase (Cpt1a) in hematopoietic cells of Vav1Cre/+Cpt1afl/fl mice limited hematopoietic progenitor proliferation and myeloid cell expansion after MI. We also observed reduced bone marrow adiposity in humans, pigs and mice after MI. Inhibiting lipolysis in adipocytes using AdipoqCreERT2Atglfl/fl mice or local depletion of bone marrow adipocytes in AdipoqCreERT2iDTR mice also curbed emergency hematopoiesis. Furthermore, systemic and regional sympathectomy prevented bone marrow adipocyte shrinkage after MI. These data establish a critical role for fatty acid metabolism in post-MI emergency hematopoiesis.