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Methodologies

Members of the working group:

  1. Will Cawthorn
  2. Claire Edwards
  3. Gina Woods
  4. Dimitrios Karampinos
  5. Olaia Naveiras
  6. Annegreet Veldhuis-Vlug
  7. Greet Kerckhofs
  8. Nathalie Bravenboer
  9. Biagio Palmisano
  10. Antonella Poloni
  11. Francoise Pflumio
  12. Jeanine Prompers
  13. Eleni Douni
  14. Izabela Podgorski
  15. Kaiyan Liu
  16. Sarah Beck
  17. Others …..

Aim(s):

Establish use of standardized methodologies related to the assessment of BMA

Approach:

The working group will identify currently used methodologies related to BMA. These will be discussed with the aim to come up with standardized protocols after which the working group writes a draft file, including the proposed methodologies that will be sent around to the BMAS EB, SB and GA members for additional feedback. If approved, the draft file can be finalized and published to guarantee future use of these methodologies globally.

Issues related to methodologies (to be completed by members):

  • Methodologies to consider for discussion include cell culture, analysis methods, such as osmium staining, Marrow Quant, MRI etc.
  • Identify subject-related factors in the methodologies that may explain inter-laboratory variation (age, sex, strain, etc.)
  • Identify environment-related factors in the methodologies that may explain inter-laboratory variation (temperature, humidity, commonly used chemicals/compounds, etc.)